Development of Ligands for the Peripheral Benzodiazepine Receptor
نویسندگان
چکیده
منابع مشابه
Imaging of a glioma using peripheral benzodiazepine receptor ligands.
Two types of benzodiazepine receptors have been demonstrated in mammalian tissues, one which is localized on neuronal elements in brain and the other, on glial cells and in peripheral tissues such as kidney. In vivo administration of 3H-labeled PK 11195 [1-(2-chlorophenyl-N-methyl-N-(1-methylpropyl)-3-isoquinoline carboxamide] or [3H]flunitrazepam with 5 mg of clonazepam per kg to rats with int...
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To obtain drugs which are more selective at benzodiazepine (BZD) receptors, design and synthesis of functionally selective ligands for BZD receptors is the current strategy of our pharmaceutical chemistry department. The affinity of newly synthesized ligands is assessed by radioligand receptor binding assays. Based on our previous studies, 2-phenyl-5-oxo-7-methyl-1,3,4-oxadiazolo[a,2,3]-pyrimid...
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To obtain drugs which are more selective at benzodiazepine (BZD) receptors, design and synthesis of functionally selective ligands for BZD receptors is the current strategy of our pharmaceutical chemistry department. The affinity of newly synthesized ligands is assessed by radioligand receptor binding assays. Based on our previous studies, 2-phenyl-5-oxo-7-methyl-1,3,4-oxadiazolo[a,2,3]-pyrimid...
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Rappaport Family Institute for Research in the Medical Sciences, Haifa, Israel (M.G.); Department of Pharmacology (M.G., I.B., R.S., L.V.) and Laboratory for Research in Anesthesia, Pain and Neuroscience (Y.K.), The Bruce Rappaport Faculty of Medicine, TechnionIsrael Institute of Technology, Haifa, Israel; Department of Anesthesiology, Ha’Emek Medical Center, Afula, Israel (Y.K.); Endocrinology...
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Viruses mercilessly exploit their host cells to guarantee their own proliferation and propagation. To achieve this goal, many viruses suppress the apoptotic program, thereby avoiding premature death of the host cell. Indeed, apopto-sis of infected cells may be considered as a pristine defense against infectious pathogens, as illustrated by a simple Gedankenexperiment : if all host cells died im...
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ژورنال
عنوان ژورنال: Current Medicinal Chemistry
سال: 2006
ISSN: 0929-8673
DOI: 10.2174/092986706777584979